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A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)

Hence, it is the need of the hour to address concerns like tea ingredient stability, efficacy, and accessibility (Ali et al., 2022)

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APOE4s role in energy metabolism is particularly significant, but more research is needed to fully elucidate the molecular mechanisms involved and to explore the effects of APOE2 and other recently identified protective APOE variants