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A deficiency can be caused either by diseases that increase the need for glutathione, or by nutrient deficiencies required for synthesis, but also by diseases that inhibit its formation.Additionally, smoking increases the use rate of glutathione, both in the detoxification of nicotine and in the neutralization of free radicals produced by tobacco smoke

However, this amount can increase for those with B12 absorption issues, pregnant or breastfeeding women, and others with increased physiological needs

Being that it is a tripeptide its especially amusing that many of the popular quick-fix cleanse and detox programs marketed to uninformed consumers are low in protein

As discussed in gut health research more broadly, microbiome disruption drives: Intestinal permeability Systemic inflammation Impaired neurotransmitter production Immune dysregulation In the context of long COVID, gut dysfunction may represent both a consequence of the initial infection and an ongoing driver of systemic inflammatory and neurological symptoms

TABLE 1 Characterization of evidence included in this narrative review