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Their first question was, Is it legal? And I was like, Yes, it's legal, Collins said

Even when late-stage data look strong, the FDA still reviews efficacy, adverse events, manufacturing, labeling, contraindications, drug interactions, and risk-management requirements

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Opioid analgesics act through G-protein-coupled receptors ( (MOR), (DOR), and (KOR)) expressed in central and peripheral neurons [52]