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Liu M, Chu J, Gu Y, Shi H, Zhang R, Wang L, Chen J, Shen L, Yu P, Chen X, Ju W, Wang Z (2017) Serum N 1-Methylnicotinamide is associated with coronary artery disease in chinese patients

Glucocorticoid-like activity of Escin: A new mechanism for an old drug

Int J Mol Sci 23(8):4121

This can significantly reduce blood pooling in the legs, improve oxygen delivery to the brain, and lessen the compensatory adrenaline surges that cause tachycardia and heart palpitations