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Future work should include expert-driven evaluations of the identified KERs using the BH criteria, covering aspects such as biological plausibility, essentiality, empirical support (e.g., doseresponse and temporal patterns), and overall coherence across studies

Acetaldehyde and ROS generated during alcohol metabolism can directly stimulate KCs and HSCs, promoting the transcription and secretion of TNF- [124, 125]

Many nutritional/dietary supplements may be contaminated with banned substances not listed on the label

In mature erythrocytes, PKC induces eryptosis by stimulating Ca 2+ signaling [255, 256]

To further increase the ERG yield, we focused next on reinforcing the sulfur metabolic flux toward ERG biosynthesis, because this pathway was indicated to be the rate-limiting pathway in our previous study 26