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Regarding U-87MG, a clear separation of the exometabolome was observed in the PCA analysis comparing U-87MG cells transfected with the anti- GLS1 siRNA and the controls (control and lipofectamine) (Fig

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Using cryo-electron microscopy (cryo-EM), we resolve the high-resolution structure of CTP-bound hCTPS1 filaments, uncovering the molecular details of CTP binding and its role in filament assembly

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In the Diazinon-only group consistent with previous studies (27,28), liver tissue damage, hepatocytes show massive vacuolar degeneration in both the centrilobular and periportal areas, correlated with the observed increase in liver weight, suggesting that pesticide-induced liver injury leads to edema and inflammatory cell infiltration