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The R665E, K669E and R676A/K677A/K678A/R679A/K680A mutants of BRD4 ET however lost their ability to bind DNA (Fig

10.1002/mnfr.201801049 56 GipsonI

The two compounds activate distinct somatotroph receptors (GHRH-R and GHS-R1a), producing additive GH release in published rodent and primate models without the cortisol or prolactin spillover seen with earlier GHRPs, because they couple to different intracellular signalling cascades