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Our study uncovers a mechanism of de-repression of PP5 phosphatase activity in plants and animals by the HOP co-chaperone and reveals dual functions of PP5 in dephosphorylating CRCK3 and stabilizing SUMM2 for immune activation

Protein Name: Glutathione S-transferase P

Most native proteins have marginally stable folding patterns, and the accumulation of misfolded proteins can disrupt intracellular protein homeostasis networks, thereby inducing various diseases [13]

doi: 10.3389/fmed.2022.1035400 Received 02 September 2022 Accepted 14 November 2022 Published 30 November 2022 Volume 9 - 2022 Edited by Ondrej Viklicky, Institute for Clinical and Experimental Medicine (IKEM), Czechia Reviewed by Roman Reindl-Schwaighofer, Medical University of Vienna, Austria