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Studies have shown that autism is predominantly a genetic disorder, with 40-80% heritability

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In SLE (systemic lupus erythematosus), ferroptosis occurs in neutrophils as a result of autoantibody and interferon-alpha induced binding of CREM (cAMP response element modulator ) to the GPx4 promoter, leading to inhibition of GPx4 expression and elevation of lipid reactive oxygen species, and SLE also induces osteoclast ferroptosis through downregulation of GPx4, leading to vertebral osteoporosis

& Assou, S