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GSH probably engages a partnership with Grx3 and Grx4, with which it forms in vitro unusual FeSbridged dimeric complexes that are coordinated by its Cys residue and the glutaredoxin active site ones (Li et al , 2009

That said, the clinical trial doses (1mg/day) are higher than what most research protocols use today and there's good reason for that gap, which we'll get into