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(Removed: "immunotherapy") Fraternale A, Paoletti MF, Casabianca A, et al

Abnormal mitochondrial physiology in the pathogenesis of systemic lupus erythematosus

In this study, variability in the response to the acute challenge with MSG vs

Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)