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PGRN, a member of the adipokine family, has gained attention for its elevated expression in GBM tissues compared with that in normal brain tissue, where it is correlated with increased tumor cell proliferation, pathological grading, and disease severity

It allows pyruvate and glutamate to be transported out of muscle tissue to the liver where gluconeogenesis takes place to supply the muscle tissue with more glucose (here reported as increased in PsA vs

MTA2 triggered R-loop trans-regulates BDH1-mediated beta-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells

7 Summary and outlook The de novo serine synthesis pathway (SSP) represents a highly dynamic and precisely regulated core metabolic node across pan-cancer

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