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The choice between ingredients often depends on desired onset speed, duration of effects, and individual tolerance considerations rather than fundamental efficacy differences

Although valproate sodium has not been evaluated for safety and efficacy in the treatment of manic episodes associated with bipolar disorder, the following adverse reactions not listed above were reported by 1% or more of patients from two placebo-controlled clinical trials of divalproex sodium tablets

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Salt-sensitive hypertension: Mechanisms and effects of dietary and other lifestyle factors

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