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Research has demonstrated that in ARDS models, preventing macrophage ferroptosis may minimize tissue damage and inflammation (62)

doi: 10.3747/co.25.4096 52 CassidyRJZhangXPatelPRSheltonJWEscottCESicaGLet al

Interestingly, Zhai et al

shRNA-mediated PPAR knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

2018 Moreover, 8-OHD markedly quenched reactive oxygen species (ROS) and activated NF-E2-related factor 2 (Nrf2) so as to upregulate expression of Phase II enzymes, including heme oxygenase (HO)-1, NADH quinone dehydrogenase 1 (NQO1), and the modifier subunit of glutamate cysteine ligase (GCLM)