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However, these changes do not translate to a significant displacement of the cytoplasmic region of TM5

A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association

CBD functions as a TRPV1 agonist, desensitizing the receptor and mitigating ROS-mediated overactivation of TRP channels, which could otherwise disrupt calcium signaling and contribute to oxidative stress 167