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The addition of glutathione into an in vitro solution may not be active as an oxidant in the absence of a system to generate the oxidized form of glutathione, which exists in different compartments in a living cell

This disruption can lead to gastrointestinal upset, including increased bowel movements or loose stools, commonly known as diarrhea

The delicate structure of glutathione makes it challenging to survive the gastrointestinal tract intact

Biomed Pharmacother (2010) 64(10):65962

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