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They concluded that this IL-1B suppression by certain intravenous LNPs might indirectly cause the reduced spleen and lymph node mRNA-LNP transfection through suppressed myeloid cells infiltration into these organs

J Physiol Pharmacol 60(Suppl 7):191196 Callahan CM, Apostolova LG, Gao S, Risacher SL, Case J, Saykin AJ, Lane KA, Swinford CG, Yoder MC (2020) Novel markers of angiogenesis in the setting of cognitive impairment and dementia