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The combination therapy was able to reduce infarct volume, preserve BBB integrity, attenuate microglia activation, decrease the required tPA dose, and improve neurological outcomes, even better than tPA alone [215, 216]

This was a major safety concern , especially for a molecule developed for melanoma prevention

These myeloid immunosuppressive cells disrupt major mechanisms of immunosurveillance, including antigen presentation by dendritic cells, T-cell activation, and/or the cytotoxicity of NK cells

coli biofilm have been studied, including amikacin (AN), cephalosporins (CE), ceftazidime (CAZ), cefoperazone (CFP), cefepime (FEP), piperacillin (PEF), piperacillin-tazobactam (PTZ), ciprofloxacin (CP), gentamicin (GM), meropenem (MEM), and netilmicin (INN)