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Similarly, diallyl trisulfide (DATS), a naturally derived HDACi, increases histone acetylation, suppresses tumor angiogenesis, and significantly enhances radiotherapy efficacy in preclinical GBM models without inducing hepatotoxicity ( Collectively, these studies identify acetylation as a central epigenetic hub that integrates chromatin remodeling, signal transduction, and tumorimmune interactions to drive radioresistance

Wang, Y.J

Neuroendocrine response and the HPA axis Acute stressors rapidly result in high levels of glucocorticoid release through the activation of the hypothalamicpituitaryadrenal (HPA) axis

They may improve the quality of repaired tissue

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