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Molecules (2009) 14(6):201631

Beyond the earlier referenced dual treatments using MET and anti-PD-1/PD-L1 inhibitors for MET-dysregulated tumors, researchers are diligently working on creating new medications that simultaneously address c-MET and PD-1/PD-L1

By eliminating acetyl groups from the lysine residues of proteins, HDACs not only inhibit gene transcription, but also cause alternative post-translational lysine modifications including methylation, ubiquitination, and sumoylation [36]