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*Correspondence: Reza Mahdavi, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Statistical analysis Data are presented as mean standard deviation (SD)

Conversely, increased levels of choline and myo-inositol in the prefrontal cortex suggest neuroinflammation and glial activation, consistent with the inflammatory processes observed in METH-induced neurotoxicity ( Behavioral assessments aligned closely with these imaging findings, offering a clinical perspective on the neurological damage caused by METH abuse

Fasting or caloric restriction was shown to increase the ratio of free carnitine to acetylcarnitine in most tissues analyzed