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In addition to iron deficiency anemia, other medical conditions can cause RLS symptoms - this is called secondary RLS - for example: Chronic kidney disease and kidney failure Peripheral neuropathy Attention deficit hyperactivity disorder (ADHD) Substance use disorders Pregnancy Medication-Related Triggers: How Certain Medications Influence RLS Symptoms Certain medications have been linked to RLS, including antidepressants, antihistamines, anti-nausea medicines, and antipsychotics or neuroleptics

A postmortem study reported reduced neural mRNA expression of the tricarboxylic acid cycle enzyme malate dehydrogenase in BD [53]

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Furthermore, during aging nave T-cells show multiple alterations, including the shortening of telomeres, the reduced production of IL-2 and the diminished ability to differentiate themselves into effector-cells

In a study by Ahmed et al