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doi: 10.1056/NEJMoa1905248 50 CampisiRNolascoSPelaiaCImpellizzeriPD'AmatoMPortacciAet al

Unlike homeostatic IEC shedding where barrier integrity is maintained by rapid basolateral tight-junction protein redistribution and zipper-like replacement by neighboring cells (246, 247), necroptosis, in which several nearby IECs lose contact, has been documented to accompany TNF--induced shedding (243, 248)

Collectively, these findings establish QCN-HS gel as a safe and clinically promising nanotherapeutic with strong immunomodulatory and regenerative potential for chronic diabetic wounds