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3404-A CONNECTIVE TISSUE GROWTH FACTOR IN LIVER SINUSOIDAL ENDOTHELIAL CELLS DRIVES LIVER FIBROGENESIS AND PORTAL HYPERTENSION IN CONGESTIVE HEPATOPATHY Seiya Kato 1 , Hayato Hikita 1 , Akira Doi 2 , Kazuhiro Murai 1 , Yuki Tahata 2 , Akira Nishio 3 , Kunimaro Furuta 1 , Takahiro Kodama 2 , Tomohide Tatsumi 2 and Tetsuo Takehara 2 , (1)Osaka University, Graduate School of Medicine, (2)Osaka University Graduate School of Medicine, (3)Osaka University Graduate School of Medicine, Bethesda, MD Background: The detail mechanism of pathogenesis in congestive hepatopathy, such as right-sided heart failure, post-Fontan surgery and Budd-Chiari syndrome, remains unclear

Neopterin values in PTPS deficiency are very high when compared to controls (Table 1), ranging from 4.95 to 51.16 mmol/mol creatinine in the urine and 11 to 449 nmol/L in the CSF