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It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60

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Moe KE, Vitiello MV, Larsen LH, Prinz PN

Protein acetylation exerts profound and far-reaching effects on numerous essential cellular processes, serving as a key regulatory switch in cell physiology

The average reduction in time to fall asleep was just 2.25 minutes , a difference so small it was not considered statistically meaningful and definitely not clinically meaningful (Choi et al., 2022)