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Acknowledgements The authors have no conflict of interest to disclose.Hi dear editor of Scientific ReportsYes, we have confirmed that Figure 1 was drawn by our team, drawn by one of my co-authors listed in the authors list.Manuscript Title: Facilitating DNAzyme Transport Across the Blood-Brain Barrier with Nanoliposome TechnologyManuscript ID: ab07b083-96c7-45b2-bb3b-8580a22ebe6e v2.0

Meddings, J

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The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

However, the results of clinical trials remain mitigated while the necessity to eliminate senescent cells is still present, highlighting the fact that, several modifications in terms of strategy are essential to improve patients lifespan 5