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The vitamin D receptor (VDR)-PPAR crosstalk enhances adipocyte insulin responsiveness, while its suppression of the renin-angiotensin system lowers OS that interferes with insulin signaling (225)

It plays an important role in neutralising free radicals and reactive oxygen species (ROS)

In particular, Eadesgroup in 2011 identified and validated for the first time in MDA-MB-231 and Hs578T breast cancer cells a miRNA, miR-200a, able to target the KEAP1 3-untranslated region (3-UTR), leading to KEAP1 mRNA degradation and, consequently, NRF2 stabilization and translocation to the nucleus [178]

Heidari R, Ahmadi A, Mohammadi H, Ommati MM, Azarpira N, Niknahad H (2018) Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance

Lin Y, Yu B, Fang P, Wang J (2023) Inhibiting autophagy before it starts