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However, even in patients with severe disease, pulmonary arterial pressure is usually only modestly elevated at rest, though it may rise markedly with exercise

Measurement of Mitochondrial Oxidative Markers The activities of complex I (NADH ubiquinone reductase), complex II (succinate-coenzyme Q reductase), complex III (ubiquinol cytochrome c reductase), complex IV (cytochrome oxidase), and citrate synthase (CS) in the skeletal muscle were assessed spectrophotometrically using commercial Assay Kits (catalogue No BC0515, BC3230, BC3240, BC0945, and BC1064, respectively

Of note, a number of the clinical studies conducted to date were not controlled, comprised small sample sizes, and/or did not use human-tropic helminths

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