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Follicles that were producing progressively thinner strands could stabilize

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Even perfectly prepared reconstituted peptides can lose activity if not stored properly: Peptide solutions are generally stored for 38 weeks at +4C and several months at -20C

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It has previously been suggested that mucosal immunity tends to be short-lived and that vaccines targeted to the mucosa may be less immunogenic at these sites [43], which are limitations that need to be overcome for efficacious mucosal-targeted vaccines