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While these methods have their place, they don't address the foundational question for many researchers: what is it about the cellular environment that encourages these fibroids to grow in the first place

In vitro experiments have shown that GPX4 or FSP1 overexpression protects CD8 + T cells from ferroptosis, while application of GPX4 inhibitor significantly increases the sensitivity of T cells to ferroptosis

This phenotype resembles D-Penicillamine treatment, which promotes urinary Cu excretion in WD patients without reducing hepatic Cu levels 10

10.1016/j.jbspin.2020.105091 49 HartemannA.BensimonG.PayanC

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