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High TDO expression has been shown to impair T-cell antitumor immunity and to be correlated with poor clinical prognosis

J Neurochem 76:627636 Hirrlinger J, Resch A, Gutterer JM, Dringen R (2002a) Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells

Its high dose of acetyl-L-Carnitine increases Acetylcholine production, a key neurotransmitter in the brain