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These three isoforms of FLN in mammals show a strong homology in the entire coding sequences and possess highly conserved genomic organization ( Specifically, human FLNA, mapping to Xq28, is the first actin filament cross-linking protein identified in non-muscle cells ( The main role of FLNA, deriving from its ability to bind actin and omodimerize, is to stabilize F-actin network in a three-dimensional structure, but its functions are not limited to a structural role

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The impaired capacity of htgUGT1A -SNP mice to eliminate potential FXR or PPAR ligands may improve the PPAR-mediated mitochondrial fatty acid oxidation, hepatic fatty acid uptake, peroxisomal beta-oxidation or other crucial processes of lipid metabolism and leads to the lower degree of hepatic steatosis