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In general, these classes of medications heighten the risk for the following: High blood pressure/ cardiovascular disease Blood clot formation/ thromboembolism/pulmonary embolism High cholesterol/ dyslipidemia Heart disease Type 2 diabetes Weight gain Certain types of cancers (primarily breast and prostate cancer) Infertility/Interfertility Hepatic toxicity Contraindications As with any use of long-term hormonal therapy and associated treatments, a screening process should be in place to ascertain if the patient is appropriate for GAHT