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Research from Stanford University Medical Center found that intermittent GH pulses upregulated IGF-1 mRNA expression 2.8-fold more effectively than continuous infusion at equivalent AUC (area under curve)

However, these findings were later challenged by Pdruzzi et al

Toxicol Appl Pharmacol 287:293298 Senapati VA, Jain AK, Gupta GS, Pandey AK, Dhawan A (2015) Chromium oxide nanoparticle-induced genotoxicity and p53-dependent apoptosis in human lung alveolar cells

The authors thus hypothesize that the application of ADSCs by iontophoretic or EMDA system could be considered as a combination therapy for PD

Furthermore, it has been demonstrated that glutathione reductase can react other disulfides in addition to glutathione disulfide