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Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation

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However, such drugs can have serious side effects (motor disorders like Parkinsons disease) and are not recommended for long-term use or as a substitute for benzodiazepines

This requires some dexterity to twist the needle on and off of the syringe, but creates a tight connection between the two