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A moderate overdose of methamphetamine may induce symptoms such as: abnormal heart rhythm, confusion, difficult or painful urination, high or low blood pressure, high body temperature, over-active or over-responsive reflexes, muscle aches, severe agitation, rapid breathing, tremor, urinary hesitancy, and an inability to pass urine

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The majority of tryptophan metabolism in the gut occurs via the kynurenine and indole pathways, with the kynurenine pathway accounting for about 9095% of the metabolism, and indole-related pathways processing around 5% (Wyatt and Greathouse, 2021)