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The efficacy of combination therapy is not necessarily superior to single therapy

Thus, inhibition of hepatocyte ferroptosis significantly reduced the severity of MASH in the HFD-fed mice

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Yang R, Walder-Christensen KK, Kim N, Wu D, Lorenzo DN, Badea A, et al

Under oxidative stress, the p53 protein forms a complex with cyclophilin D (CypD) in the mitochondrial matrix, opening the mitochondrial permeability transition pore and leading to the release of mitochondrial contents, which induces cell necrosis (Wu et al., 2020