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Consistent with the above bioinformatic analyses, these results further confirm that human IDD is characterized by a redox imbalance, ferroptosis activation, and inflammatory stress, suggesting an intricate interplay among these factors throughout the IDD cascade

Cell 147 , 223234 (2011)

Indeed, pathways of regulated cell death including apoptosis and necrosis have emerged as central events in the pathogenesis of various kidney diseases that may be amenable to therapeutic intervention

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