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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

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Some of this thyroglobulin with iodine molecules attached is stored in the gland in the form of a gooey paste called colloid , which is normally located in the center of follicles, which are balls of thyroid cells with a hollow center