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Similar results were observed when tumours were implanted into the flanks of mice, a result that suggests that this phenotype is not specific to the mammary gland environment (Extended Data Fig

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Also, a crosstalk between cancer-associated fibroblasts (CAFs) and KRAS mutant cancer cells has been shown

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For instance, the E7 protein of the human papillomavirus (HPV) binds to the retinoblastoma tumour suppressor (Rb) and cyclin-dependent kinase inhibitor p21, thereby promoting DNA replication and cell proliferation [27]