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Neuronal transfection Hippocampal neurons were transfected with GEVAL plasmids using jetOPTIMUS transfection reagent according to the manufacturers specifications (PolyPlus, CA)

Heatmaps of differentially expressed genes, photosynthetic, and photorespiration genes were generated using the pheatmap v1.0.12 package ( Genes (rows) were clustered using row scaled Euclidean distance and the ward.D clustering approach

doi: 10.1107/S090744490901169X Escoubas, Pierre and King, Glenn F

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For sermorelin specifically, the three main failure modes are: Vigorous Shaking: Shaking a reconstituted GHRH analog causes mechanical shear stress