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In sepsis mouse models pretreated with Gln, the activation of CD4 + T cells was in equilibrium, and the expression of the anti-apoptotic protein Bcl-2 was more pronounced ( 3.2.3 The biological functions of glutaminolysis in CD4 + T cells T lymphocytes are a vital population of immune cells involved in immune regulation and are a key component of the adaptive immune system ( + T cells, especially the differentiation of subsets of CD4 + lymphocytes

Curr Opin Endocrinol Diabetes Obes 30(6):324329

Thus, the oxPPP plays an important role in infection-fighting and cancer-killing CD4 + and CD8 + T cells as well as in T cells driving autoimmunity

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309 Recently, Met restricted diet (MRD) has been reported to have an important role in anti-tumor immune regulation