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In particular, the oxidation of many common amino acids by the MPO released by leukocytes constitutes an main source of cytotoxic aldehydes in ventricular tissue

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And because these are biological processes, they follow their own timeline

This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation

The recurrent tumors exhibited not only upregulation of immune-escape genes, such as CD274 and CTLA4 , but also cytokine genes, such as IL6 and TNF