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Human studies have shown dose-limiting toxicities with NAMPT inhibitors, including gastrointestinal, hematologic, and metabolic effects. Animal studies also demonstrate harm to normal tissues when NAD+ production is reduced. These findings highlight a key challenge: targeting NAD+ metabolism in cancer is difficult because lowering NAD+ can harm healthy cells as much asor more thancancer cells

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Go ahead, Harlan. Harlan Krumholz: Well, I was just going to say that on the lifestyle side, though, theres a lot of overlap in terms of what represents healthy intervention

Although theres still much to learn about its full range of functions, we do know this sunshine vitamin plays a crucial role in: Bone health Cardiovascular health Regulating cell growth and development Supporting both the innate and adaptive immune systems Reducing inflammation Despite its importance, vitamin D deficiency is extremely common