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Lin X, Zhan B, Wen S, Li Z, Huang H, Feng J

Apart from its role in the immune system, NADPH is required by the enzyme glutathione reductase to regenerate reduced glutathione, a key endogenous antioxidant that protects cells from oxidative stress [13]

This sets up a vicious loop: hyperglycemia oxidative stress low GSH worse insulin resistance more hyperglycemia

The PML/RAR oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)