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For each buffer, the pH changes were similar with all three types of water

While the precise cause of PD remains elusive, mounting evidence suggests that neuroinflammatory processes, oxidative stress, and BBB leakiness play critical roles in disease onset and progression, linking vascular and immune mechanisms to neurodegeneration

For the assessment of advanced glycation endproducts (AGEs), we measured arg-pyrimidine (Arg-Pyr) and carboxymethyllysine (CML)

Additionally, NAC has shown potential benefits in treating drug and alcohol abuse, which can be relevant for individuals with multiple substance use disorders

Melatonin helps maintain oocyte integrity and functionality by scavenging ROS and enhancing endogenous antioxidant enzyme activity ( Recent studies have also shown that melatonin can improve the survival and developmental competence of oocytes derived from small antral follicles (89)