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Larger molecules based on antibody scaffolds and fragments, including PF-05231023 (190 kDa), BFKB8488A and MK-3655 (150 kDa), and efruxifermin (92 kDa) may be less likely to cross the blood-brain barrier at therapeutic doses, but their tissue distribution has not been described

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2.3 Influence of glial-related factors on PD In addition to inflammatory factors, many neurotrophic factors are associated with glial cells in Parkinsons disease