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Furthermore, future research should focus on enzymatic and non-enzymatic antioxidants

However, this approach is not without limitations, including glucocorticoid resistance, the occurrence of numerous adverse effects, suboptimal drug delivery, and other complicating factors that collectively necessitate the pursuit of innovative therapeutic avenues [6]

In the first phase, an enzyme will oxidize a portion of the toxin in order to make it more reactive and prepare it for the second phase

Viral vectors, such as the third-generation oncolytic adenovirus TS-2021 (with E1A regulated by Ki67/TGF-2 UTR and carrying IL-15), was revealed to significantly downregulate MMP3 expression by inhibiting p-MKK4/p-JNK signaling, thereby effectively suppressing the invasive ability of GBM cells (146)

This project is supported by the Grant of National Natural Science Fund of China (Grant no.82250410378), Zhenjiang key research and development plan (social development) (Grant no