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There is a great deal of evidence that a major pathogenic role in oxidative stress is played by transition metals, such as iron, copper and zinc, which catalyzes oxidation reactions also in the brain and their imbalance was frequently detected in brain tissue of AD patients thereby representing an interesting therapeutic target in AD treatment (Gutteridge, 1994

Small human studies comparing delivery forms have found higher blood glutathione levels with liposomal versions, though most of this research is still early and often industry-funded

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