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Patel Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Jenil R

Evolving Therapeutics in Multiple Myeloma Highly effective treatments are available in early-line settings of multiple myeloma management, such as proteasome inhibitors, immunomodulatory drugs (IMiDs), corticosteroids, and multiple drug combinations, including anti-CD38 antibodies, but treatment options for progressive disease following initial lines of therapy have historically been limited

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In a randomized, double-blind, placebo-controlled Phase II trial involving 204 patients with mild to moderate plaque psoriasis, daily oral administration of Serlopitanta selective NK1R antagonistled to a statistically significant yet modest reduction in psoriasis-associated pruritus, indicating that NK1R blockade alone may not fully account for the complex mechanisms of itch and that other mediators are likely to play major roles [75]

2.12 Statistical analysis The data was analyzed using the SPSS software system (version 22)